KDM4D Antibody

Code CSB-PA718355LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA718355LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA718355LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KDM4D Polyclonal antibody
Uniprot No.
Target Names
KDM4D
Alternative Names
JHD3D antibody; JHDM3D antibody; JmjC domain-containing histone demethylation protein 3D antibody; Jumonji domain-containing protein 2D antibody; Kdm4d antibody; KDM4D_HUMAN antibody; Lysine-specific demethylase 4D antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lysine-specific demethylase 4D protein (337-499AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The KDM4D Antibody (Product code: CSB-PA718355LA01HU) is Non-conjugated. For KDM4D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA718355LB01HU KDM4D Antibody, HRP conjugated ELISA
FITC CSB-PA718355LC01HU KDM4D Antibody, FITC conjugated
Biotin CSB-PA718355LD01HU KDM4D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Gene References into Functions
  1. A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice. PMID: 29599352
  2. The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex. PMID: 27679476
  3. KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance PMID: 27630312
  4. KDM4D-RNA interaction is required for KDM4D accumulation at DNA breakage sites PMID: 25714495
  5. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. PMID: 24550317
  6. The molecular basis for JMJD2 site specificity revealed by X-ray crystallography. PMID: 23219879
  7. Results demonstrate that JMJD2D can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer PMID: 22514644
  8. identified two related histone demethylases, JMJD2A and JMJD2D PMID: 17555712

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Subcellular Location
Nucleus.
Protein Families
JHDM3 histone demethylase family
Database Links

HGNC: 25498

OMIM: 609766

KEGG: hsa:55693

STRING: 9606.ENSP00000334181

UniGene: Hs.503598

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