KHDRBS2 Antibody, FITC conjugated

Code CSB-PA730139LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KHDRBS2 Polyclonal antibody
Uniprot No.
Target Names
KHDRBS2
Alternative Names
KH domain containing; RNA binding; signal transduction associated protein 2 antibody; 6330586C16Rik antibody; bA535F17.1 antibody; FLJ38664 antibody; hSLM 1 antibody; hSLM-1 antibody; KH domain containing; RNA binding; signal transduction associated 2 antibody; KH domain-containing antibody; KHDR2_HUMAN antibody; khdrbs2 antibody; MGC26664 antibody; RNA-binding antibody; Sam68 like mammalian protein 1 antibody; Sam68-like mammalian protein 1 antibody; signal transduction-associated protein 2 antibody; SLM 1 antibody; SLM-1 antibody; SLM1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein (1-349AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.
Gene References into Functions
  1. molecular cloning and characterization PMID: 12549823
Subcellular Location
Nucleus.
Protein Families
KHDRBS family
Tissue Specificity
Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.
Database Links

HGNC: 18114

OMIM: 610487

KEGG: hsa:202559

STRING: 9606.ENSP00000281156

UniGene: Hs.519794

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