KIF18A Antibody

1. High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. PMID: 29466986
2. Low post translational modifications of KIF18A protein is associated with neoplasms. PMID: 28209915
3. KIF18a role in microtubule assembly PMID: 26912793
4. Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. PMID: 25048371
5. Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. PMID: 25884224
6. data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules PMID: 25208566
7. a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival PMID: 25431949
8. that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif PMID: 25281536
9. the motion of yeast (Kip3) and human (Kif18A) kinesin-8s PMID: 23746518
10. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. PMID: 23288039
11. Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner. PMID: 22595673
12. there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation PMID: 22104080
13. Kif18A controls spindle length independently of its role in chromosome positioning. This is mediated by an ATP-independent spindle microtubule (MT) binding site at C-terminal end of the Kif18A tail that has a strong affinity for MTs in vitro and in cells. PMID: 21885282
14. The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. PMID: 21884977
15. Kif18A overexpression is associated with colorectal cancer progression. PMID: 21213216
16. Kinesin (KIF18A) can be potentially used as a blood biomarker to identify asbestosis patients at risk of developing lung cancer. PMID: 21231887
17. High Kif18A is associated with breast carcinogenesis. PMID: 20595236
18. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. PMID: 20153196
19. Kif18A is a dual-functional kinesin and a key component of chromosome congression. PMID: 17346968
20. Kif18A regulates kinetochore microtubule dynamics to control mitotic chromosome positioning. PMID: 18267093
21. The current study sheds light on MS-KIF18A a microtubule-dependent kinesin and adds insights on the post-translational modifications that potentially control the protein cellular distribution and its co-association with cytoskeletal proteins. PMID: 18680169
22. Studies strongly suggest that chromosome congression defects as the result of KIF18A depletion is at least in part mediated through destabilizing kinetochore CENP-E. PMID: 19625775

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HGNC: 29441

OMIM: 611271

KEGG: hsa:81930

STRING: 9606.ENSP00000263181

UniGene: Hs.301052