KIF18A Antibody

Code CSB-PA012315GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
KIF18A
Alternative Names
AU024633 antibody; B130001M12Rik antibody; DKFZp434G2226 antibody; KI18A_HUMAN antibody; KIF 18A antibody; KIF18A antibody; kinesin family member 18A antibody; Kinesin like protein KIF18A antibody; Kinesin-like protein KIF18A antibody; Marrow stromal KIF18A antibody; MGC27627 antibody; MS KIF18A antibody; MS-KIF18A antibody; RGD1561740 antibody; RP23 206C1.1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human KIF18A
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
Gene References into Functions
  1. High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. PMID: 29466986
  2. Low post translational modifications of KIF18A protein is associated with neoplasms. PMID: 28209915
  3. KIF18a role in microtubule assembly PMID: 26912793
  4. Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. PMID: 25048371
  5. Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. PMID: 25884224
  6. data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules PMID: 25208566
  7. a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival PMID: 25431949
  8. that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif PMID: 25281536
  9. the motion of yeast (Kip3) and human (Kif18A) kinesin-8s PMID: 23746518
  10. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. PMID: 23288039
  11. Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner. PMID: 22595673
  12. there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation PMID: 22104080
  13. Kif18A controls spindle length independently of its role in chromosome positioning. This is mediated by an ATP-independent spindle microtubule (MT) binding site at C-terminal end of the Kif18A tail that has a strong affinity for MTs in vitro and in cells. PMID: 21885282
  14. The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. PMID: 21884977
  15. Kif18A overexpression is associated with colorectal cancer progression. PMID: 21213216
  16. Kinesin (KIF18A) can be potentially used as a blood biomarker to identify asbestosis patients at risk of developing lung cancer. PMID: 21231887
  17. High Kif18A is associated with breast carcinogenesis. PMID: 20595236
  18. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. PMID: 20153196
  19. Kif18A is a dual-functional kinesin and a key component of chromosome congression. PMID: 17346968
  20. Kif18A regulates kinetochore microtubule dynamics to control mitotic chromosome positioning. PMID: 18267093
  21. The current study sheds light on MS-KIF18A a microtubule-dependent kinesin and adds insights on the post-translational modifications that potentially control the protein cellular distribution and its co-association with cytoskeletal proteins. PMID: 18680169
  22. Studies strongly suggest that chromosome congression defects as the result of KIF18A depletion is at least in part mediated through destabilizing kinetochore CENP-E. PMID: 19625775

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Subcellular Location
Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Database Links

HGNC: 29441

OMIM: 611271

KEGG: hsa:81930

STRING: 9606.ENSP00000263181

UniGene: Hs.301052

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