KIF1BP Antibody, Biotin conjugated

Code CSB-PA836204LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KIF1BP Polyclonal antibody
Uniprot No.
Target Names
KIF1BP
Alternative Names
Hypothetical protein LOC26128 antibody; KBP antibody; KBP_HUMAN antibody; KIAA1279 antibody; KIF1-binding protein antibody; TTC20 antibody; Uncharacterized protein KIAA1279 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human KIF1-binding protein (24-204AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Gene References into Functions
  1. Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length. PMID: 28445502
  2. Data suggest that KBP functions as a kinesin inhibitor that modulates MT-based cargo motility and depolymerizing activity of a subset of kinesin motors. We propose that misregulation of KBP-controlled kinesin motors may represent the underlying molecular mechanism that contributes to the neuropathological defects observed in Goldberg-Shprintzen syndrome patients. PMID: 26948876
  3. A report on fetal cases with a homozygous mutation in KBP gene in a consanguineous Pakistani family with isolated polymicrogyria. PMID: 24072599
  4. KBP-cytoskeleton interactions is involved in neuronal development in Goldberg-Shprintzen syndrome. PMID: 23427148
Involvement in disease
Goldberg-Shprintzen syndrome (GOSHS)
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
KIF1-binding protein family
Tissue Specificity
Highly expressed in heart, brain, ovary, testis, spinal cord and all specific brain regions examined. Moderate expressed at intermediate level in all other adult tissues examined, as well as in fetal liver and brain. Not expressed in blood leukocytes.
Database Links

HGNC: 23419

OMIM: 609367

KEGG: hsa:26128

STRING: 9606.ENSP00000354848

UniGene: Hs.279580

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