KIF24 Antibody, FITC conjugated

Datasheet

Code	CSB-PA716354LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KIF24 Polyclonal antibody

Uniprot No.

Q5T7B8

Target Names

KIF24

Alternative Names

bA571F15.4 antibody; C9orf48 antibody; Kif24 antibody; KIF24_HUMAN antibody; kinesin family member 24 antibody; Kinesin-like protein KIF24 antibody; RP11-571F15.7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kinesin-like protein KIF24 protein (1168-1368AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle.

Gene References into Functions

Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization. PMID: 26290419
Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly. PMID: 21620453
KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic Lobar Degeneration PMID: 20670673
Observational study of gene-disease association. (HuGE Navigator) PMID: 20670673

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family

Database Links

HGNC: 19916

OMIM: 613747

KEGG: hsa:347240

STRING: 9606.ENSP00000368464

UniGene: Hs.710246

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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