KIRREL3 Antibody

Datasheet

Code	CSB-PA811640LA01HU
Size	US$166
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Image	Immunofluorescence staining of HepG2 cells with CSB-PA811640LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KIRREL3 Polyclonal antibody

Uniprot No.

Q8IZU9

Target Names

KIRREL3

Alternative Names

KIRREL3 antibody; KIAA1867 antibody; NEPH2 antibody; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3 antibody; Kin of irregular chiasm-like protein 3 antibody; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kin of IRRE-like protein 3 protein (200-343AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KIRREL3 Antibody (Product code: CSB-PA811640LA01HU) is Non-conjugated. For KIRREL3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA811640LB01HU	KIRREL3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA811640LC01HU	KIRREL3 Antibody, FITC conjugated
Biotin	CSB-PA811640LD01HU	KIRREL3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

Gene References into Functions

KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. PMID: 25488023
Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported. PMID: 19012874

Involvement in disease

Mental retardation, autosomal dominant 4 (MRD4)

Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.

Database Links

HGNC: 23204

OMIM: 607761

KEGG: hsa:84623

STRING: 9606.ENSP00000435466

UniGene: Hs.376015

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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