KIRREL3 Antibody

Code CSB-PA012372GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
KIRREL3
Alternative Names
KIRREL3 antibody; KIAA1867 antibody; NEPH2 antibody; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3 antibody; Kin of irregular chiasm-like protein 3 antibody; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human KIRREL3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
Gene References into Functions
  1. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
  2. Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. PMID: 25488023
  3. Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported. PMID: 19012874
Involvement in disease
Mental retardation, autosomal dominant 4 (MRD4)
Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.
Protein Families
Immunoglobulin superfamily
Tissue Specificity
Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.
Database Links

HGNC: 23204

OMIM: 607761

KEGG: hsa:84623

STRING: 9606.ENSP00000435466

UniGene: Hs.376015

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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