KLLN Antibody

1. Data suggest that low levels of PTEN and KLLN are associated with both sporadic papillary thyroid carcinoma and multi-nodular goiter (as compared to control subjects); however, PTEN and KLLN should not be considered as circulating biomarkers for differential diagnosis between malignancy and benignity in indeterminate thyroid nodules. (PTEN = phosphatase and tensin homolog; KLLN = DNA replication inhibitor killin) PMID: 28755140
2. The results suggest a critical role for KLLN as a potential regulator of pericentric heterochromatin formation, genomic stability and gene expression. PMID: 26673699
3. overexpression of microRNA-224 enhanced the proliferation abilities of HO8910 and knockdown of microRNA-224 suppressed the proliferation abilities of HO8910PM by KLLN-cyclin A pathway. PMID: 27663866
4. Germline promoter hypermethylation of KLLN is associated with particular malignant and benign Cowden syndrome features, which is dependent on the PTEN mutation status. PMID: 25669429
5. Killin has a role in competitively inhibiting the formation of DNA replication forks during S-phase, as well as potentially negatively regulate RNA synthesis during other cell cycle phases PMID: 25945611
6. Data indicate that NVP-BEZ235-induced androgen receptor (AR) suppression resulted in decreased expression of both tumor suppressor proteins PTEN and KLLN in AR+/ER+ breast cancer cells. PMID: 24356815
7. Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma PMID: 24972837
8. We demonstrate, in vitro and in murine xenograph models, that both KLLN and PTEN are AR-target genes, mediating androgen-induced growth inhibition and apoptosis in breast cancer cells. PMID: 23418309
9. Germline KLLN mutations dysregulate the cell cycle at G2. PMID: 23446638
10. KLLN is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis. PMID: 23386643
11. Pathogenic mutations in KLLN are rare in breast cancer families and the c.339_340delAG variant does not represent a high-penetrance breast cancer risk allele. PMID: 22580995
12. Cowden syndrome patients have elevated risks of papillary thyroid cancer from KLLN alterations. PMID: 21956414
13. 19 of 20 advanced RCC showed somatic hypermethylation upstream of KILLIN PMID: 21584899
14. Germline KILLIN methylation is common among patients with Cowden syndrome or Cowden-like syndrome and is associated with increased risks of breast and renal cancer over PTEN mutation-positive individuals PMID: 21177507
15. results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21. PMID: 18385383
16. Killin is a p53-regulated nuclear inhibitor of DNA synthesis with high affinity of DNA binding. PMID: 18385383

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HGNC: 37212

OMIM: 612105

KEGG: hsa:100144748

STRING: 9606.ENSP00000392204

UniGene: Hs.559820