KLRC3 Antibody

Code CSB-PA23099A0Rb
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • IHC image of CSB-PA23099A0Rb diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA23099A0Rb at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) KLRC3 Polyclonal antibody
Uniprot No. Q07444
Target Names KLRC3
Alternative Names Killer cell lectin like receptor subfamily C member 3 antibody; KLRC 3 antibody; KLRC3 antibody; NK cell receptor E antibody; NKG2 E activating NK receptor antibody; NKG2 E antibody; NKG2 E type II integral membrane protein antibody; NKG2-E type II integral membrane protein antibody; NKG2-E-activating NK receptor antibody; NKG2E activating NK receptor antibody; NKG2E antibody; NKG2E type II integral membrane protein antibody; NKG2E_HUMAN antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human NKG2-E type II integral membrane protein (94-240AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Gene References into Functions
  1. KLRC3 gene expression is linked to glioblastoma aggressiveness. PMID: 27641066
  2. Data indicate that NKG2 receptor NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum. PMID: 24935923
  3. Data indicate that the expression of KLRD1 (CD94) and NKG2E (KLRC3) was reduced in NK-enriched cells in fulminant type 1 diabetes. PMID: 24177169
Subcellular Location Membrane, Single-pass type II membrane protein
Tissue Specificity Natural killer cells.
Database Links

HGNC: 6376

OMIM: 602892

KEGG: hsa:3823

STRING: 9606.ENSP00000437563

UniGene: Hs.654362

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