KMT2B Antibody, Biotin conjugated

1. Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex. PMID: 28976802
2. Summary of variants in KMT2B associated with dystonia, as well as the clinical phenotype (review) PMID: 29289525
3. Rare missense variation in KMT2B represents an additional cause of generalized dystonia. PMID: 28520167
4. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
5. we describe a method to seamlessly modify a putative CDK2 phosphorylation site on MLL2 to restrict its phosphorylation and activation. Specifically, by utilizing dimeric CRISPR RNA-guided nucleases, RFNs (commercially known as the NextGENtrade mark CRISPR), in combination with an excision-only piggyBactrade mark transposase, we demonstrate how to generate a point mutation of threonine-542, a predicted site to prevent M... PMID: 27075976
6. The crucial role of KMT2B in the physiological control of voluntary movement. PMID: 27992417
7. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer. PMID: 28124401
8. Results show that KMT2B interacts with ERalpha to bind the ERalpha-binding sites of IL-20 and other ERalpha target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20, and other ERalpha-responsive genes, in breast cancer cells. PMID: 27806114
9. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B; moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis PMID: 27839873
10. The results explain how the MLL SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 lysine. PMID: 26320581
11. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
12. We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. PMID: 26180087
13. HBV-MLL4 integration occurred frequently in Chinese HCC patients, representing a unique molecular segment for HCC with HBV infection PMID: 25901726
14. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth. PMID: 25139254
15. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation. PMID: 23426673
16. knockdown of MLL4 severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells. PMID: 22713656
17. Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2 PMID: 19060922
18. data suggest that the translocation breakpoint of MLL4 gene is one of the preferential targets for HBV DNA integration into the MLL4 gene and the HBV DNA integration may be involved in liver oncogenesis PMID: 18320596

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HGNC: 15840

OMIM: 606834

KEGG: hsa:9757

STRING: 9606.ENSP00000222270

UniGene: Hs.676457