KMT2B Antibody, Biotin conjugated

Code CSB-PA890939LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KMT2B Polyclonal antibody
Uniprot No.
Target Names
KMT2B
Alternative Names
Histone-lysine N-methyltransferase 2B antibody; HRX2 antibody; KIAA0304 gene product antibody; KMT2B antibody; KMT2B_HUMAN antibody; Likely ortholog of mouse WW domain binding protein 7 antibody; Lysine N-methyltransferase 2B antibody; mixed lineage leukemia 4 antibody; Mixed lineage leukemia gene homolog 2 protein antibody; MLL2 antibody; myeloid lymphoid leukemia 4 antibody; Myeloid lymphoid or mixed lineage leukemia protein 4 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 4 antibody; Trithorax homolog 2 antibody; trithorax homologue 2 antibody; TRX2 antibody; WBP-7 antibody; WBP7 antibody; WW domain-binding protein 7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Histone-lysine N-methyltransferase 2B protein (145-290AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
Gene References into Functions
  1. Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex. PMID: 28976802
  2. Summary of variants in KMT2B associated with dystonia, as well as the clinical phenotype (review) PMID: 29289525
  3. Rare missense variation in KMT2B represents an additional cause of generalized dystonia. PMID: 28520167
  4. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
  5. we describe a method to seamlessly modify a putative CDK2 phosphorylation site on MLL2 to restrict its phosphorylation and activation. Specifically, by utilizing dimeric CRISPR RNA-guided nucleases, RFNs (commercially known as the NextGENtrade mark CRISPR), in combination with an excision-only piggyBactrade mark transposase, we demonstrate how to generate a point mutation of threonine-542, a predicted site to prevent M... PMID: 27075976
  6. The crucial role of KMT2B in the physiological control of voluntary movement. PMID: 27992417
  7. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer. PMID: 28124401
  8. Results show that KMT2B interacts with ERalpha to bind the ERalpha-binding sites of IL-20 and other ERalpha target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20, and other ERalpha-responsive genes, in breast cancer cells. PMID: 27806114
  9. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B; moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis PMID: 27839873
  10. The results explain how the MLL SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 lysine. PMID: 26320581
  11. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
  12. We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. PMID: 26180087
  13. HBV-MLL4 integration occurred frequently in Chinese HCC patients, representing a unique molecular segment for HCC with HBV infection PMID: 25901726
  14. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth. PMID: 25139254
  15. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation. PMID: 23426673
  16. knockdown of MLL4 severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells. PMID: 22713656
  17. Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2 PMID: 19060922
  18. data suggest that the translocation breakpoint of MLL4 gene is one of the preferential targets for HBV DNA integration into the MLL4 gene and the HBV DNA integration may be involved in liver oncogenesis PMID: 18320596

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Subcellular Location
Nucleus.
Protein Families
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
Tissue Specificity
Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocyte
Database Links

HGNC: 15840

OMIM: 606834

KEGG: hsa:9757

STRING: 9606.ENSP00000222270

UniGene: Hs.676457

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