L1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA08349D0Rb
Size US$299
Uniprot No. P03101
Protocols ELISA Protocol
Immunogen Recombinant Human papillomavirus type 16 Major capsid protein L1 protein (6-471AA)
Raised in Rabbit
Species Reactivity Human papillomavirus type 16
Tested Applications ELISA
Relevance Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Major capsid protein L1, L1
Immunogen Species Human papillomavirus type 16
Research Area Microbiology
Target Names L1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Subcellular Location Virion, Host nucleus
Protein Families Papillomaviridae L1 protein family

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