AFG1L Antibody, FITC conjugated

Code CSB-PA819895LC01HU
Size US$166
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Product Details

Uniprot No.
Alternative Names
AFG1 antibody; ATPase family gene 1 homolog antibody; CG8520 gene product antibody; lace1 antibody; LACE1_HUMAN antibody; Lactation elevated protein 1 antibody; Lactivation elevated 1 antibody; Protein AFG1 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human AFG1-like ATPase protein (14-313AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
Gene References into Functions
  1. Increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis. PMID: 27323408
  2. This study establishes LACE1 as a novel factor with a crucial role in mitochondrial protein homeostasis. PMID: 26759378
  3. association between bipolar disorder and two SNPs in the gene LACE1 PMID: 20872768
  4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  8. Observational study of genetic testing. (HuGE Navigator) PMID: 18237552

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Subcellular Location
Mitochondrion membrane.
Protein Families
AFG1 ATPase family
Database Links

HGNC: 16411

OMIM: 617469

KEGG: hsa:246269

STRING: 9606.ENSP00000357973

UniGene: Hs.259666

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