LARP6 Antibody, FITC conjugated

Code CSB-PA887112LC01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LARP6 Polyclonal antibody
Uniprot No.
Target Names
LARP6
Alternative Names
Acheron antibody; Achn antibody; FLJ11196 antibody; La ribonucleoprotein domain family member 6 antibody; La-related protein 6 antibody; LARP6 antibody; LARP6_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human La-related protein 6 protein (294-453AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Gene References into Functions
  1. Study shows that mTORC1 phosphorylates La ribonucleoprotein domain family, member 6 to stimulate type I collagen expression. PMID: 28112218
  2. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. PMID: 28782243
  3. Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen PMID: 26932461
  4. We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process. PMID: 25271881
  5. Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA. PMID: 25692237
  6. The study presents the structure of the La motif and RRM1 of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1. PMID: 25488812
  7. LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle PMID: 24469459
  8. The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. PMID: 23887937
  9. Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing. PMID: 22139627
  10. Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization. PMID: 21387291
  11. LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop. PMID: 19917293
  12. Acheron may influence differentiation in part via its control of cell adhesion dynamics. PMID: 19889961
  13. These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals. PMID: 17383118

Show More

Hide All

Subcellular Location
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity
Expressed in numerous tissues.
Database Links

HGNC: 24012

OMIM: 611300

KEGG: hsa:55323

STRING: 9606.ENSP00000299213

UniGene: Hs.416755

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*