LHFPL5 Antibody

Code CSB-PA844703LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA844703LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA844703LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA844703LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LHFPL5 Polyclonal antibody
Uniprot No.
Target Names
LHFPL5
Alternative Names
LHFPL5; TMHS; LHFPL tetraspan subfamily member 5 protein; Lipoma HMGIC fusion partner-like 5 protein; Tetraspan membrane protein of hair cell stereocilia
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human LHFPL tetraspan subfamily member 5 protein (46-99AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LHFPL5 Antibody (Product code: CSB-PA844703LA01HU) is Non-conjugated. For LHFPL5 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA844703LB01HU LHFPL5 Antibody, HRP conjugated ELISA
FITC CSB-PA844703LC01HU LHFPL5 Antibody, FITC conjugated
Biotin CSB-PA844703LD01HU LHFPL5 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation.
Gene References into Functions
  1. two novel variants in LHFPL5, including a unique 3'-UTR splice site variant that is predicted to impact pre-mRNA splicing and regulation through an extended 3'-UTR. PMID: 30177809
  2. These findings provide a novel function of LHFPL2 and a novel genetic basis for distal reproductive tract development; they also emphasize the importance of an additional merging phase for proper reproductive tract development. PMID: 26964900
  3. LHFPL5 mutation is associated with dysequilibrium syndrome type 2 and sensorineural hearing loss. PMID: 26437881
  4. Five microsatellites in the 6p21.31e22.3 region and screening of the LHFPL5 gene by DNA heteroduplex analysis revealed a novel mutation (c.89dup) in one out of 129 unrelated Tunisian families with autosomal recessive nonsyndromic hearing loss. PMID: 21816241
  5. These findings establish the importance of TMHS for normal sound transduction in humans. PMID: 16459341
  6. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies PMID: 19102128
  7. The authors present an overview of the LHFP gene family in mouse and humans PMID: 15905332

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Involvement in disease
Deafness, autosomal recessive, 67 (DFNB67)
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
LHFP family
Database Links

HGNC: 21253

OMIM: 609427

KEGG: hsa:222662

STRING: 9606.ENSP00000353346

UniGene: Hs.367947

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