LLGL1 Antibody

Code CSB-PA831655
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA831655(LLGL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA831655(LLGL1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
LLGL1
Alternative Names
DLG4 antibody; DLG4, formerly antibody; Hugl 1 antibody; HUGL antibody; Hugl-1 antibody; HUGL1 antibody; Human homolog to the D-lgl gene protein antibody; L2GL1_HUMAN antibody; Lethal giant larvae homolog 1 (Drosophila) antibody; Lethal giant larvae homolog 1 antibody; Lethal(2) giant larvae protein homolog 1 antibody; LLGL antibody; Llgl1 antibody; Ly 49G2 antibody; Ly49G2 antibody; Mgl1 antibody; Mlgl antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human LLGL1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Gene References into Functions
  1. loss of Llgl1 results in EGFR mislocalization, promoting pre-neoplastic changes PMID: 27542214
  2. these results revealed that miR-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 PMID: 26934648
  3. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. PMID: 28628235
  4. Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage. PMID: 26662669
  5. Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent. PMID: 25982280
  6. this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy. PMID: 26341367
  7. Lgl1 has a role in inhibiting glioblastoma PMID: 25426552
  8. PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C in glioblastoma cells. PMID: 23907540
  9. Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo. PMID: 23864775
  10. inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia PMID: 23277453
  11. Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival PMID: 22843887
  12. Hugl-1 can act as a tumour suppressor in Drosophila and thus is the functional homologue of lgl PMID: 15467749
  13. downregulation of Hugl-1 contributes to colorectal cancer progression PMID: 15735678
  14. loss of Hugl-1 expression contributes to melanoma progression PMID: 16170365
  15. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia PMID: 17369850
  16. loss of Hugl-1 expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis. PMID: 18074678
  17. Results provide the first evidence that Hugl-1 mRNA is frequently mutated by aberrant splicing exclusively in HCC, which may be involved in HCC progression. PMID: 19447873

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Subcellular Location
Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton.
Protein Families
WD repeat L(2)GL family
Tissue Specificity
Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
Database Links

HGNC: 6628

OMIM: 600966

KEGG: hsa:3996

STRING: 9606.ENSP00000321537

UniGene: Hs.513983

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