LMAN2L Antibody, FITC conjugated

Code CSB-PA863945LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LMAN2L Polyclonal antibody
Uniprot No.
Target Names
LMAN2L
Alternative Names
LMAN2L antibody; VIPL antibody; PSEC0028 antibody; UNQ368/PRO704 antibody; VIP36-like protein antibody; Lectin mannose-binding 2-like antibody; LMAN2-like protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human VIP36-like protein (45-313AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
Gene References into Functions
  1. Homozygous missense mutation p.R53Q in the LMAN2L gene causes autosomal recessive intellectual disability and seizures. PMID: 26566883
  2. Study showed a significant association between LMAN2L and risk of both bipolar disorder and schizophrenia PMID: 24914473
  3. The results of this study suggested that significant novel association signals near the genes LMAN2L and provide supportive evidence for the previously reported association signals near ANK3 and within the 3p21.1 locus. PMID: 22182935
  4. VIPL terminates in the sequence KRFY, characteristic for proteins recycling between the ER and ERGIC/cis-Golgi; and knock-down of VIPL mRNA slowed secretion of two glycoproteins (35 and 250 kDa), suggesting that VIPL may function as an ER export receptor. PMID: 12878160
  5. selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence. PMID: 18025080

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Involvement in disease
Mental retardation, autosomal recessive 52 (MRT52)
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Tissue Specificity
Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
Database Links

HGNC: 19263

OMIM: 609552

KEGG: hsa:81562

STRING: 9606.ENSP00000366280

UniGene: Hs.655743

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