LPHN1 Antibody

Datasheet

Code	CSB-PA008270
Size	US$100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O94910

Target Names

ADGRL1

Alternative Names

Calcium independent alpha latrotoxin receptor 1 antibody; Calcium-independent alpha-latrotoxin receptor 1 antibody; CIRL-1 antibody; CIRL1 antibody; CL1 antibody; CLIBA antibody; G protein-coupled receptor for alpha-Latrotoxin antibody; KIAA0821 antibody; Latrophilin 1 antibody; Latrophilin-1 antibody; Latrophilin1 antibody; LEC2 antibody; Lectomedin 2 antibody; Lectomedin-2 antibody; LPHN 1 antibody; LPHN1 antibody; LPHN1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Latrophilin-1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IF, ELISA

Recommended Dilution

Application	Recommended Dilution
IF	1:200-1:1000
ELISA	1:5000

Protocols

Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis.

Gene References into Functions

alterations in latrophilin expression occur in AML cells expressing P-gp PMID: 29938681
Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia PMID: 27322212
A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma. PMID: 27325752
In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex. PMID: 20971062

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Database Links

HGNC: 20973

OMIM: 616416

KEGG: hsa:22859

STRING: 9606.ENSP00000340688

UniGene: Hs.94229

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy G protein coupled receptor signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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