LRAT Antibody, FITC conjugated

Datasheet
Code CSB-PA013069LC01HU
Size US$299
Uniprot No. O95237
Protocols ELISA Protocol
Immunogen Recombinant Human Lecithin retinol acyltransferase protein (24-182AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase), LRAT
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names LRAT
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
Involvement in disease Leber congenital amaurosis 14 (LCA14)
Subcellular Location Endoplasmic reticulum membrane, Single-pass membrane protein, Rough endoplasmic reticulum, Endosome, multivesicular body, Cytoplasm, perinuclear region
Protein Families H-rev107 family
Tissue Specificity Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed
Database Links

HGNC: 6685

OMIM: 604863

KEGG: hsa:9227

STRING: 9606.ENSP00000337224

UniGene: Hs.658427

Related Products

LRAT Antibodies

LRAT Antibodies for Homo sapiens (Human)

LRAT Proteins

LRAT Proteins for Homo sapiens (Human)

LRAT ELISA Kit

LRAT ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.