LRRC4C Antibody, HRP conjugated

Code CSB-PA888027LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LRRC4C Polyclonal antibody
Uniprot No.
Target Names
LRRC4C
Alternative Names
LRRC4C; KIAA1580; NGL1; UNQ292/PRO331; Leucine-rich repeat-containing protein 4C; Netrin-G1 ligand; NGL-1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leucine-rich repeat-containing protein 4C protein (201-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May promote neurite outgrowth of developing thalamic neurons.
Gene References into Functions
  1. These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders. PMID: 27759917
  2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
  3. netrin-G1 functions as an important component of the NGL-1 receptor to promote TCA outgrowth and that membrane-bound netrins can participate in receiving axonal signaling pathways. PMID: 14595443
  4. NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons. PMID: 14595443
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show v
Database Links

HGNC: 29317

OMIM: 608817

KEGG: hsa:57689

STRING: 9606.ENSP00000278198

UniGene: Hs.745123

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