LSM10 Antibody

Code CSB-PA836169LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA836169LA01HU at dilution of 1:100

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Product Details

Uniprot No.
Alternative Names
LSM10U7 snRNA-associated Sm-like protein LSm10 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 protein (1-123AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LSM10 Antibody (Product code: CSB-PA836169LA01HU) is Non-conjugated. For LSM10 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836169LB01HU LSM10 Antibody, HRP conjugated ELISA
FITC CSB-PA836169LC01HU LSM10 Antibody, FITC conjugated
Biotin CSB-PA836169LD01HU LSM10 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Gene References into Functions
  1. FLASH plays two roles in 3' end processing of histone pre-mRNAs: It interacts with Lsm11 to form a docking platform for the polyadenylation factors, and it cooperates with SLBP to recruit U7 snRNP to histone pre-mRNA. PMID: 28289156
  2. Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 and SMN complexes PMID: 16087681
  3. The overexpression of Lsm10 and Lsm11 increases the cellular levels of U7 snRNP but has no effect on histone pre-mRNA processing. PMID: 16914750
  4. The subnuclear organization of histone gene regulatory proteins and 3' end processing factors (NPAT/LSM10) of normal somatic and embryonic stem cells is compromised in selected human cancer cell types. PMID: 19277982
  5. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. PMID: 11574479

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Subcellular Location
Nucleus.
Protein Families
SnRNP Sm proteins family
Database Links

HGNC: 17562

OMIM: 617909

KEGG: hsa:84967

STRING: 9606.ENSP00000319341

UniGene: Hs.603131

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