Ltbp1 Antibody, Biotin conjugated

1. LTBP1 has a role in female reproduction PMID: 27956181
2. Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions. PMID: 25805620
3. Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. PMID: 24262428
4. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
5. miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. PMID: 23183523
6. High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
7. results suggest a role for VEGFA-driven tumour growth by TGF-beta signalling inhibition via paracrine mechanisms in vivo PMID: 22045186
8. Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling. PMID: 22036565
9. requirement for TGF-beta signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance PMID: 21422469
10. Ltbp1L is a major regulator of Tgf-beta activity during valvulogenesis since its absence results in a perturbed Tgf-beta pathway that causes all Ltbp1L(-/-) valvular defects. PMID: 21181942
11. Shows that Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the early limb bud. PMID: 20565961
12. IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system PMID: 12962157
13. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions PMID: 15677465
14. integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1 requires fibronectin PMID: 16260650
15. Cleavage of LTBP1 by BMP1 is involved in TGFbeta1 activation. PMID: 17015622
16. Data show that the lack of Ltbp1L in the extracellular matrix of the septating cardiac outflow tract and associated vessels results in altered gene expression and function of cardiac neural crest cells and decreased Tgf-beta activity in the OFT. PMID: 17804598
17. LTBP-1 has essential functions in the control of TGF-beta activation PMID: 17950478
18. AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. PMID: 18508077
19. Blocking Tgfb-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. PMID: 18516051
20. When TGF-beta activity would inhibit further maturation and mineralization, LTBP-1 containing large latent TGF-beta1 complexes that accumulate into the ECM and represent targets for osteoclast mediated release and activation of TGF-beta in bone tissue. PMID: 18672106
21. Data suggest that association of latent TGF-beta binding protein (LTBP) with the latent TGF-beta complex is important for proper TGF-beta1 function. PMID: 19022904
22. The long form of LTBP1 (LTBP-1L) is essential for proper heart development. PMID: 17804598

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KEGG: mmu:268977

STRING: 10090.ENSMUSP00000001927

UniGene: Mm.269747