MAB21L1 Antibody, HRP conjugated

Code CSB-PA623800LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MAB21L1 Polyclonal antibody
Uniprot No.
Target Names
MAB21L1
Alternative Names
MAB21L1 antibody; CAGR1 antibody; Nbla00126Putative nucleotidyltransferase MAB21L1 antibody; EC 2.7.7.- antibody; Protein mab-21-like 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Putative nucleotidyltransferase MAB21L1 protein (1-359AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye. It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA).
Gene References into Functions
  1. Mab21l1-/- osteoblasts also expressed higher levels of adipocyte genes and interferon-regulated genes at early stages of osteogenesis PMID: 29156428
  2. offer a structure-based explanation for the effects of MAB21L2 mutations in patients with eye malformations PMID: 27271801
  3. mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. [review] PMID: 27558071
  4. We hypothesize that MAB21L1 haploinsufficiency cause a previously undescribed syndrome with scrotal agenesis, ophthalmological anomalies, facial dysmorphism and gross psychomotor delay as remarkable hallmarks. PMID: 27103078
  5. MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression. PMID: 21465527

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Subcellular Location
Nucleus.
Protein Families
Mab-21 family
Tissue Specificity
Expressed in brain, cerebellum and skeletal muscle.
Database Links

HGNC: 6757

OMIM: 601280

KEGG: hsa:4081

STRING: 9606.ENSP00000369251

UniGene: Hs.584776

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