MAN2C1 Antibody, HRP conjugated

Code CSB-PA878885LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MAN2C1 Polyclonal antibody
Uniprot No.
Target Names
MAN2C1
Alternative Names
MAN2C1 antibody; MANA antibody; MANA1Alpha-mannosidase 2C1 antibody; EC 3.2.1.24 antibody; Alpha mannosidase 6A8B antibody; Alpha-D-mannoside mannohydrolase antibody; Mannosidase alpha class 2C member 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alpha-mannosidase 2C1 protein (746-969AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.
Gene References into Functions
  1. MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes PMID: 27355585
  2. Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling. PMID: 23486476
  3. MAN2C1 binds PTEN thereby inhibiting its phosphatidylinositol 3,4,5 triphosphate phosphatase activity PMID: 21556061
  4. MAN2C1 methylation levels modify cumulative traumatic burden on risk of post traumatic stress disorder PMID: 21508515
  5. regulation of Man2C1 expression is essential for maintaining efficient protein N-glycosylation PMID: 20978011
  6. Reduced antibody response to BSA was observed in transgenic mice, suggesting that specific antibody response to tumor antigens might be suppressed by hMan2c1 transgene. PMID: 19572206
  7. plays an important role in preventing oncosis-like death in BJAB cells PMID: 12643454
  8. Results suggest that inhibition of alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat T cells. PMID: 16721356
  9. Inhibition of MAN2C1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis. PMID: 19018777

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Subcellular Location
Cytoplasm.
Protein Families
Glycosyl hydrolase 38 family
Database Links

HGNC: 6827

OMIM: 154580

KEGG: hsa:4123

STRING: 9606.ENSP00000267978

UniGene: Hs.26232

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