MAP3K12 Antibody

1. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. PMID: 28641113
2. REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase PMID: 27100796
3. miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. PMID: 25999017
4. Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration. PMID: 25341110
5. these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins. PMID: 21893036
6. The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK expression and the clinical course of the disease. PMID: 21526495
7. the DLK-ERK signaling pathway may act as a regulator of the interaction that occurs between Hsp27 and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function PMID: 19675578
8. for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity PMID: 14697235
9. ZIPK is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity. PMID: 15611134
10. DLK is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification PMID: 15695824
11. DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression. PMID: 18995835
12. Src-dependent tyrosine phosphorylation recombinant human DLK was important for regulation of its activity. DLK may have a role in PDGF signaling. PMID: 19146952

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HGNC: 6851

OMIM: 600447

KEGG: hsa:7786

STRING: 9606.ENSP00000448689

UniGene: Hs.713539