MARK4 Antibody

Datasheet

Code	CSB-PA265569
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA265569(MARK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q96L34

Target Names

MARK4

Alternative Names

FLJ90097 antibody; KIAA1860 antibody; MAP / microtubule affinity regulating kinase 4 antibody; MAP / microtubule affinity regulating kinase 4L antibody; MAP/microtubule affinity regulating kinase 4 antibody; MAP/microtubule affinity regulating kinase like 1 antibody; MAP/microtubule affinity-regulating kinase 4 antibody; MAP/microtubule affinity-regulating kinase-like 1 antibody; MARK 4 antibody; MARK 4L antibody; MARK L1 antibody; MARK4 antibody; MARK4 serine / threonine protein kinase antibody; MARK4 serine/threonine protein kinase antibody; MARK4_HUMAN antibody; MARK4S antibody; MARKL 1 antibody; MARKL1 antibody; Nbla00650 antibody; Putative protein product of Nbla00650 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human MARK4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT/TAU. Also phosphorylates the microtubule-associated proteins MAP2 and MAP4. Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles. Required for the initiation of axoneme extension during cilium assembly. Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro. Plays a role in cell cycle progression, specifically in the G1/S checkpoint. Reduces neuronal cell survival. Plays a role in energy homeostasis by regulating satiety and metabolic rate. Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway. Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation.

Gene References into Functions

data demonstrate that miR-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types PMID: 26882547
Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP/TAZ activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells. PMID: 28183853
Atypical PKC phosphorylates serine-threonine residues of MARK4. PMID: 26346160
Suggest role for polypyrimidine-tract binding protein in regulating alternative splicing of MARK4 in gliomas. PMID: 25578778
MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition. PMID: 25123532
Molecular dynamic simulation data predicted the three dimensional structure for the kinase domain of MARK4 and its structural properties. PMID: 24763618
A strong and significant elevation of MARK4 expression and MARK4-tau interactions in AD brains correlates with the Braak stages of the disease, suggesting that the MARK4-tau interactions are of functional importance in the progression of AD. PMID: 23666762
MARK4 is a critical positive regulator of early steps in ciliogenesis. PMID: 23400999
MARK4 is a new negative regulator of mTORC1 PMID: 23184942
The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis. PMID: 22156016
Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer. PMID: 22506312
Observational study, meta-analysis, and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20460622
demonstrated that the endogenous MARK4L colocalizes with centrosomes at all mitotic stages and resides in centrosome-enriched fractions. PMID: 19759416
Normally expressed in neural progenitors, re-expressed in gliomas and may become a target of amplification upon chr. 19 rearrangement. PMID: 12735302
MARK4 is likely to be directly involved in microtubule organization in neuronal cells PMID: 14594945
NUAK1 and MARK4 are substrates of USP9X PMID: 18254724

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Cell projection, dendrite.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily

Tissue Specificity

Ubiquitous. Isoform 2 is brain-specific. Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen.

Database Links

HGNC: 13538

OMIM: 606495

KEGG: hsa:57787

STRING: 9606.ENSP00000262891

UniGene: Hs.34314

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Protein Service

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Protein Phosphorylation: The Dynamic Language of Cellular Regulation Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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