MATN2 Antibody

Datasheet

Code	CSB-PA013521LA01HU
Size	US$166
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Image	IHC image of CSB-PA013521LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MATN2 Polyclonal antibody

Uniprot No.

O00339

Target Names

MATN2

Alternative Names

Crtm2 antibody; MATN 2 antibody; Matn2 antibody; MATN2_HUMAN antibody; Matrilin-2 antibody; Matrilin2 antibody; MGC102477 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Matrilin-2 protein (746-867AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MATN2 Antibody (Product code: CSB-PA013521LA01HU) is Non-conjugated. For MATN2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013521LB01HU	MATN2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013521LC01HU	MATN2 Antibody, FITC conjugated
Biotin	CSB-PA013521LD01HU	MATN2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in matrix assembly.

Gene References into Functions

findings showed that YopK binds to the cell surface-exposed endogenous MATN2 and that purified YopK protein strongly inhibits the bacterial adherence to HeLa cells PMID: 28533472
Data show that the mRNA and protein levels of matrilin-2 were increased after irradiation treatment in both mouse lung tissue and human pulmonary alveolar epithelial cells (HPAEpiC). PMID: 27923659
Taken together, our results showed that high-glucose-induced Matrilin-2 expression that was mediated by the TGF-beta1/Smad3 signaling pathway might play a role in Diabetic nephropathy (DN) pathogenesis and our finding provided a potential diagnostic and/or therapeutic target for DN. PMID: 27105914
Matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal, partly through a TLR4-mediated mechanism PMID: 26271809
matrilin-2, a filament-forming protein widely distributed in extracellular matrices. PMID: 11852232
matrilin-2 is expressed in normal skin by keratinocytes and fibroblasts and may thus contribute to cutaneous homeostasis. PMID: 12164922
study of interactions by which matrilin-2 can be integrated into extracellular filamentous networks PMID: 12180907
These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive pilocytic astrocytoma. PMID: 16401863
DeltaNp63/BMP-7 signaling pathway modulates wound healing process through the regulation of matrilin-2. PMID: 18328806
data indicate matrilin-2 is a novel basement membrane component in the liver, synthesized during sinusoidal "capillarization" in cirrhosis & in hepatocellular carcinoma PMID: 18386166

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Subcellular Location

Secreted.

Database Links

HGNC: 6908

OMIM: 602108

KEGG: hsa:4147

STRING: 9606.ENSP00000430487

UniGene: Hs.189445

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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