MCF2L Antibody

Datasheet

Code	CSB-PA521145ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA521145ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA521145ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MCF2L Polyclonal antibody

Uniprot No.

O15068

Target Names

MCF2L

Alternative Names

ARHGEF 14 antibody; DBL''s big sister antibody; DBS antibody; FLJ12122 antibody; Guanine nucleotide exchange factor DBS antibody; KIAA0362 antibody; MCF 2L antibody; MCF.2 cell line derived transforming sequence like antibody; MCF.2 transforming sequence-like antibody; MCF2 like protein antibody; MCF2 transforming sequence like protein antibody; MCF2-transforming sequence-like protein antibody; Mcf2l antibody; MCF2L_HUMAN antibody; OST antibody; OST oncogene antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Guanine nucleotide exchange factor DBS protein (850-980AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42.; Does not catalyze guanine nucleotide exchange on CDC42.

Gene References into Functions

When compared to the gemcitabine-sensitive cells, the gemcitabine-resistant cells had a higher level of MCF2L expression, suggesting that MCF2L plays an important role in gemcitabine resistance PMID: 29039610
A rare variant in MCF2L has been identified using exclusion linkage in a pedigree with premature atherosclerosis. PMID: 25898923
MCF2L is subject to a cis-acting eQTL in synovial membrane that correlates with the OA association signal. This signal contains several functional SNPs that could account for the susceptibility and which therefore merit further investigation PMID: 26584642
A single nucleotide polymorphism in MCF2L is associated with osteoarthritis. PMID: 21871595
Dbs is activated by Rac1 at the pleckstrin homology domain PMID: 14701795
the guanine nucleotide exchange factor Ost has a role in negative regulation of receptor endocytosis by the small GTPase Rac1 PMID: 17562712

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Subcellular Location

[Isoform 5]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 3]: Cytoplasm. Endomembrane system.; Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

MCF2 family

Database Links

HGNC: 14576

OMIM: 609499

KEGG: hsa:23263

STRING: 9606.ENSP00000440374

UniGene: Hs.170422

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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