MCUB Antibody

Code CSB-PA873671LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA873671LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA873671LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MCUB Polyclonal antibody
Uniprot No.
Target Names
MCUB
Alternative Names
MCUB; CCDC109B; Calcium uniporter regulatory subunit MCUb, mitochondrial; MCUb; Coiled-coil domain-containing protein 109B
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MCUB Antibody (Product code: CSB-PA873671LA01HU) is Non-conjugated. For MCUB Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA873671LB01HU MCUB Antibody, HRP conjugated ELISA
FITC CSB-PA873671LC01HU MCUB Antibody, FITC conjugated
Biotin CSB-PA873671LD01HU MCUB Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Gene References into Functions
  1. This study elucidated a role for CCDC109B as an oncogene and a prognostic marker in human gliomas. PMID: 28754121
  2. MCUb (also known as CCDC109b) is a paralogue of MCU (CCDC109a). MCUb physically resides within the mitochondrial uniporter complex (uniplex), which consists of the MCU, MCUb, EMRE, MICU1, and MICU2. PMID: 24231807
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
MCU (TC 1.A.77) family
Database Links

HGNC: 26076

KEGG: hsa:55013

STRING: 9606.ENSP00000378145

UniGene: Hs.234149

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