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MEAF6 Antibody, FITC conjugated

Datasheet
Code CSB-PA872530LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MEAF6 Polyclonal antibody
Uniprot No.
Q9HAF1
Target Names
MEAF6
Alternative Names
MEAF6 antibody; C1orf149 antibody; CENP-28 antibody; EAF6Chromatin modification-related protein MEAF6 antibody; MYST/Esa1-associated factor 6 antibody; Esa1-associated factor 6 homolog antibody; Protein EAF6 homolog antibody; hEAF6 antibody; Sarcoma antigen NY-SAR-91 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Chromatin modification-related protein MEAF6 protein (113-174AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Gene References into Functions
  1. These findings suggest that the MEAF6-1 variant does not induce neuroendocrine differentiation of prostate cancer cells, but rather facilitates t-NEPC progression by increasing the proliferation rate of cells that have acquired neuroendocrine phenotypes. PMID: 28427194
  2. present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS PMID: 24530230
Involvement in disease
A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.
Subcellular Location
Nucleus, nucleolus. Chromosome, centromere, kinetochore.
Protein Families
EAF6 family
Database Links

HGNC: 25674

OMIM: 611001

KEGG: hsa:64769

UniGene: Hs.17118

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