MED13 Antibody

Code CSB-PA080113
Size US$100
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Product Details

Uniprot No.
Target Names
MED13
Alternative Names
MED13 antibody; ARC250 antibody; KIAA0593 antibody; THRAP1 antibody; TRAP240 antibody; Mediator of RNA polymerase II transcription subunit 13 antibody; Activator-recruited cofactor 250 kDa component antibody; ARC250 antibody; Mediator complex subunit 13 antibody; Thyroid hormone receptor-associated protein 1 antibody; Thyroid hormone receptor-associated protein complex 240 kDa component antibody; Trap240 antibody; Vitamin D3 receptor-interacting protein complex component DRIP250 antibody; DRIP250 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human TRAP240.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Gene References into Functions
  1. Each of HSPA4 and MED13 mutations were detected in GC. PMID: 27129500
  2. Cardiac overexpression of MED13 in transgenic mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue and liver PMID: 25422356
  3. Med12 and Med13 are critical for human CDK8 subcomplex -dependent repression, whereas CDK8 kinase activity is not PMID: 19240132
Subcellular Location
Nucleus.
Protein Families
Mediator complex subunit 13 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 22474

OMIM: 603808

KEGG: hsa:9969

STRING: 9606.ENSP00000380888

UniGene: Hs.282678

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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