MED15 Antibody, HRP conjugated

Datasheet

Code	CSB-PA842753LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MED15 Polyclonal antibody

Uniprot No.

Q96RN5

Target Names

MED15

Alternative Names

MED15 antibody; ARC105 antibody; CTG7A antibody; PCQAP antibody; TIG1 antibody; TNRC7 antibody; Mediator of RNA polymerase II transcription subunit 15 antibody; Activator-recruited cofactor 105 kDa component antibody; ARC105 antibody; CTG repeat protein 7a antibody; Mediator complex subunit 15 antibody; Positive cofactor 2 glutamine/Q-rich-associated protein antibody; PC2 glutamine/Q-rich-associated protein antibody; TPA-inducible gene 1 protein antibody; TIG-1 antibody; Trinucleotide repeat-containing gene 7 protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Mediator of RNA polymerase II transcription subunit 15 protein (433-530AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.

Gene References into Functions

MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma PMID: 29400661
MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells. PMID: 27974704
MED15 as a potential biomarker for head and neck squamous cell carcinoma PMID: 26457685
MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors PMID: 26377566
MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression. PMID: 25791637
these findings implicate MED15 in CRPC, and as MED15 is evolutionary conserved, it is likely to emerge as a lethal phenotype in other therapeutic-resistant diseases, and not restricted to our disease model. PMID: 24374838
MED15 and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 protein misfolding and proteotoxicity in vitro and in vivo. PMID: 22916034
The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
Methylation of TIG1 in prostatic neoplasms correlates with methylation of the retinoic acid receptor beta gene. PMID: 14691453
Limited role of exon 7 PCQAP polymorphisms in the pathogenesis of schizophrenia. PMID: 15318033
TIG1 gene Silencing by promoter hypermethylation is associated with nasopharyngeal carcinoma PMID: 15455391
SREBPs use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes PMID: 16799563
results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling PMID: 16904669
The protein encoded by this gene was identified as ARC105, a 105kDa component of the Activator-Recruited Cofactor (ARC) that is involved in mediating gene activation by several classes of transcriptional regulators. PMID: 10235267

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Mediator complex subunit 15 family

Tissue Specificity

Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and k

Database Links

HGNC: 14248

OMIM: 607372

KEGG: hsa:51586

STRING: 9606.ENSP00000263205

UniGene: Hs.517421

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