MESP2 Antibody

Datasheet

Code	CSB-PA613150ESR1HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MESP2 Polyclonal antibody

Uniprot No.

Q0VG99

Target Names

MESP2

Alternative Names

Basic helix loop helix protein MESP 2 antibody; Basic helix loop helix protein MESP2 antibody; BHLH protein MesP2 antibody; bHLHc6 antibody; Class C basic helix-loop-helix protein 6 antibody; Hypothetical class II basic helix loop helix protein MESP 2 antibody; Hypothetical class II basic helix loop helix protein MESP2 antibody; Mesoderm posterior 2 antibody; mesoderm posterior 2 homolog (mouse) antibody; Mesoderm posterior 2 homolog antibody; Mesoderm posterior protein 2 antibody; Mesp 2 antibody; MESP2 antibody; MESP2_HUMAN antibody; SCDO 2 antibody; SCDO2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Mesoderm posterior protein 2 protein (218-397AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Gene References into Functions

Mutated MESP2 causes spondylocostal dysostosis PMID: 15122512
Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo. PMID: 16996494
findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome PMID: 18485326

Involvement in disease

Spondylocostal dysostosis 2, autosomal recessive (SCDO2)

Subcellular Location

Nucleus.

Database Links

HGNC: 29659

OMIM: 605195

KEGG: hsa:145873

STRING: 9606.ENSP00000342392

UniGene: Hs.37311

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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