MFF Antibody, FITC conjugated

Code CSB-PA013751LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MFF Polyclonal antibody
Uniprot No.
Target Names
MFF
Alternative Names
C2orf33 antibody; Chromosome 2 open reading frame 33 antibody; DKFZp666J168 antibody; GL004 antibody; Mff antibody; MFF_HUMAN antibody; MGC110913 antibody; Mitochondrial fission factor antibody; OTTHUMP00000164235 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Mitochondrial fission factor protein (1-322AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Gene References into Functions
  1. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. PMID: 28262828
  2. expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues PMID: 29496454
  3. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations PMID: 26783368
  4. membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
  5. Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). PMID: 25912308
  6. loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria PMID: 26008206
  7. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. PMID: 25431021
  8. TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PMID: 23284813
  9. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
  10. MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS production, and the onset of autophagy and mitophagy. PMID: 22878233
  11. MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
  12. Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes. PMID: 18353969

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Involvement in disease
Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
Subcellular Location
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein Families
Tango11 family
Tissue Specificity
Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
Database Links

HGNC: 24858

OMIM: 614785

KEGG: hsa:56947

STRING: 9606.ENSP00000302037

UniGene: Hs.471528

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