MGAT5 Antibody, Biotin conjugated

Code CSB-PA600992LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MGAT5 Polyclonal antibody
Uniprot No. Q09328
Target Names MGAT5
Alternative Names 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A antibody; 6-N-acetylglucosaminyltransferase antibody; Alpha 1,3(6) mannosylglycoprotein antibody; Alpha 1,6 mannosylglycoprotein 6 beta N acetylglucosaminyltransferase antibody; Alpha mannoside beta 1,6 N acetylglucosaminyltransferase antibody; Alpha-1 antibody; Alpha-mannoside beta-1 antibody; Beta 1,6 N acetyl glucosaminyltransferase antibody; GGNT5 antibody; GlcNAc T V antibody; GlcNAc-T V antibody; GNT V antibody; GNT VA antibody; GNT-V antibody; GNTV antibody; GNTVA antibody; Mannoside acetylglucosaminyltransferase 5 antibody; Mannosyl (alpha 1,6) glycoprotein beta 1,6 N acetyl glucosaminyltransferase antibody; Mgat5 antibody; MGT5A_HUMAN antibody; N acetylglucosaminyl transferase V antibody; N acetylglucosaminyltransferase V mannosyl (alpha 1,6) glycoprotein antibody; N-acetylglucosaminyl-transferase V antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A protein (107-217AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
Gene References into Functions
  1. The best homology model is consistent with available experimental data. The three-dimensional model, the structure of the enzyme catalytic site and binding information obtained for the donor and acceptor can be useful in studies of the catalytic mechanism and design of inhibitors of GnT-V. PMID: 26821880
  2. Our data suggest that oxidative stress induces the overexpression of MGAT5 via the regulation of the focal adhesion kinase-extracellular signal-regulated kinase signaling pathway, which, in turn, affects the function of endothelial cells, which then participates in the pathogenesis of preeclampsia. PMID: 27334383
  3. PTPalpha is identified as a novel substrate of N-Acetylglucosaminyltransferase V (GnT-V) and could be a factor regulating promotion of migration in breast cancer cells PMID: 27965091
  4. Tunicamycin, an inhibitor of N-glycan biosynthesis, was also able to enhance the radiosensitivity of U251 cells. Thus, our results suggest that development of therapeutic approaches targeting N-linked beta1,6-GlcNAc branches which are encoded by N-acetylglucosaminyltransferase V may be a promising strategy in glioblastoma treatment PMID: 26526581
  5. the knockdown of GnTV significantly suppressed the proliferation, migration and invasion (P<0.05) of the SMMC7721/R cells. PMID: 26531171
  6. role in the inhibition of trophoblast cell invasion and migration during early pregnancy by direct or indirect regulation of MMP2/9 activity PMID: 26349781
  7. the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation PMID: 26583147
  8. Mgat5 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
  9. Gnt-V caused tumour growth more quickly PMID: 26293457
  10. High expression of GnT-V was observed in infiltrating cells in skin section samples from systemic and localized patients with scleroderma. PMID: 25876794
  11. MGAT5 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
  12. Human Mgat5 increases amino acid uptake, intracellular levels of glycolytic and TCA intermediates, as well as HEK293 cell growth. PMID: 25395405
  13. Study disclose that a deficiency in branched N-glycosylation on TCR due to a reduced MGAT5 gene expression is a new molecular mechanism underlying UC pathogenesis. PMID: 24334766
  14. The results identified Mgat5-mediated beta-1-6-GlcNAc branched N-glycosylation and following activation of EGFR as a potential novel upstream molecular event for PAK1-induced anoikis resistance in hepatoma cells. PMID: 23811795
  15. These results contribute to new insight into the underlying molecular mechanisms of GnT-V regulation in gastric cancer with potential translational clinical applications. PMID: 24399258
  16. GnT-V plays a significant role in metastasis and invasion in gastric cancer cells. PMID: 23563846
  17. The combination of intratumoral MGAT5 expression and TNM or Kiel staging systems had a better predictive power for overall survival. PMID: 23107376
  18. GnT-V directs cancer progression by modulating MMPs in cancer. PMID: 23357422
  19. The results of this study have shown that the MGAT5 intronic variants rs4953911 and rs3814022 correlate with lower N-glycan branching, reduced surface CTLA-4 in human CD4 + T cell blasts, and associate with multiple sclerosis. PMID: 23351704
  20. Data show that knockdown of CD147 inhibited MMP-2 activity of GnT-V-overexpressing cells, indicating that aberrant beta1,6-branches on CD147 is crucial for the induction of MMPs (matrix metalloproteinases) in SMMC-7721 cells. PMID: 23005037
  21. The results suggest that GnT-V may be a potential target for predicting nasopharyngeal carcinoma response to radiotherapy. PMID: 22780953
  22. These data suggested that GnT-V expression was positively related with malignancy in human hepatocellular carcinoma (HCC) and GnT-V may be both a differentiation marker and a potential target for the treatment of HCC. PMID: 22537550
  23. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
  24. Inhibiting expression of N-acetylglucosaminyltransferase V inhibits the proliferation of PC-3 cells. PMID: 20584650
  25. GnT-V expression is positively correlated with malignancy in nasopharyngeal carcinoma cells PMID: 21676538
  26. Findings suggest Mgat5 may play an important role during oncogenesis, identifying a potential therapeutic target for pulmonary adenocarcinoma. PMID: 21631992
  27. The rs1257169(G) allele of MGAT5 is associated with lower disease severity in multiple sclerosis PMID: 21115203
  28. The GnT-V was fully active without exogenous cation and in the presence of EDTA, and pH optimum for GnT-V was in the range of 6.5-7.0. PMID: 19846580
  29. Our results suggest that GnT-V could decrease human hepatoma SMMC-7721 cell adhesion and promote cell proliferation partially through RPTPkappa. PMID: 19911372
  30. Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching PMID: 11864986
  31. A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. PMID: 11872751
  32. Low GnT-V expression is associated with shorter survival and poor prognosis in pStage I overall Non-small cell lung cancer. PMID: 15014031
  33. Data describe the effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases involved in the synthesis of surface sialyl Lewis X antigen. PMID: 15044007
  34. GlcNAc-transferase-V activity is up-regulated in RA and Vit-D(3)-treated hepatoma cell lines. PMID: 15313475
  35. GnT-V would contribute to placentation in the early phase of pregnancy, possibly regulating the process of invasion of trophoblast cells PMID: 15809094
  36. These results supported the mechanism that blocking of GnT-V expression impaired functions of chaperones and N-glycan-synthesizing enzymes, which caused UPR in vivo. PMID: 16467879
  37. GnT-V is closely related to low malignant potential and good prognosis of the patients with bladder cancer. PMID: 16638859
  38. Glycosylation caused by GnT-V directs integrin beta1 stability and more delivery to plasma membrane, subsequently promotes Fn-based cell migration and invasion. PMID: 16924681
  39. glycosylation change & decrease of transport activity of GLUT1 may be 1 possible mechanism of ER stress induced by down-regulating GnT-V, & GnT-V may contribute to the regulation of glucose uptake by modifying glycosylation of GLUT1 in some tumor cells. PMID: 17451637
  40. We investigated mRNA levels of glycosyltransferases, namely GnT-V, and found that it's expression was decreased in HLE-cells resistant to Epirubicin as well as in HLE-cells resistant to Mitoxantrone. PMID: 17488527
  41. Tissue inhibitor of metalloproteinase-1 (TIMP-1), was identified as a target protein for GnT-V in human colon cancer cell WiDr. PMID: 17878270
  42. Results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome. PMID: 17971775
  43. Knock-down of MGAT5 in PC-3 cells attenuated the metastatic ability of prostate cancer cells, as determined by the in vitro invasion assay and the xenograft animal studies. PMID: 18649738
  44. GnT-V expression is correlated with a poor prognosis in gastric cancer patients due to metastases. PMID: 18931531
  45. decreased GnT-Va activity due to siRNA expression in human carcinoma cells inhibits ligand-induced EGFR internalization, consequently resulting in delayed downstream signal transduction and inhibition of the EGF-induced, invasiveness-related phenotypes. PMID: 19225046
  46. overexpression of GnT-V in a hepatoma cell line not only induced the addition of beta1,6 GlcNAc branch to N-glycan of RPTPkappa but also decreased the protein level of RPTPkappa PMID: 19236842
  47. High expression of N-acetylglucosaminyltransferase V is associated with mucinous tumors of the ovary. PMID: 19787216

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Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyltransferase 18 family
Database Links

HGNC: 7049

OMIM: 601774

KEGG: hsa:4249

STRING: 9606.ENSP00000281923

UniGene: Hs.4988

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