MIF4GD Antibody

Code CSB-PA013827LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MIF4GD Polyclonal antibody
Uniprot No.
Target Names
MIF4GD
Alternative Names
MIF4GD antibody; SLIP1 antibody; MIF4G domain-containing protein antibody; SLBP-interacting protein 1 antibody; hSLIP1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human MIF4G domain-containing protein (1-133AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MIF4GD Antibody (Product code: CSB-PA013827LA01HU) is Non-conjugated. For MIF4GD Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA013827LB01HU MIF4GD Antibody, HRP conjugated ELISA
FITC CSB-PA013827LC01HU MIF4GD Antibody, FITC conjugated
Biotin CSB-PA013827LD01HU MIF4GD Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Gene References into Functions
  1. Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC. PMID: 24336329
  2. Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required. PMID: 23286197
  3. This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the authors demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo. PMID: 23286197
  4. INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs. PMID: 22532700
  5. downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability. PMID: 18025107

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
MIF4GD family
Database Links

HGNC: 24030

OMIM: 612072

KEGG: hsa:57409

UniGene: Hs.325631

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