MKLN1 Antibody, FITC conjugated

Code CSB-PA890926LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MKLN1 Polyclonal antibody
Uniprot No.
Target Names
MKLN1
Alternative Names
MKLN 1 antibody; Mkln1 antibody; MKLN1_HUMAN antibody; muskelin 1, intracellular mediator containing kelch motifs antibody; Muskelin antibody; TWA2 antibody; Two-hybrid-associated protein with Ranbpm 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Muskelin protein (488-614AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Gene References into Functions
  1. A meta-analysis genome wide association study suggest MKLN1 is associated with early-onset bipolar disorder. PMID: 27769005
  2. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells PMID: 17467196
  3. These novel findings identify a role for muskelin-RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication. PMID: 18710924
Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Nucleus, nucleoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Cell junction, synapse. Cell junction, synapse, postsynapse.
Database Links

HGNC: 7109

OMIM: 605623

KEGG: hsa:4289

STRING: 9606.ENSP00000323527

UniGene: Hs.44693

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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