MLST8 Antibody, Biotin conjugated

Code CSB-PA863130LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MLST8 Polyclonal antibody
Uniprot No.
Target Names
MLST8
Alternative Names
G protein beta subunit like antibody; G protein beta subunit-like antibody; Gable antibody; GbetaL antibody; GBL antibody; GBL protein antibody; LST8 antibody; LST8_HUMAN antibody; Mammalian lethal with SEC13 protein 8 antibody; MGC111011 antibody; mLST8 antibody; MTOR associated protein LST8 homolog (S. cerevisiae) antibody; POP3 antibody; POP3 homolog (S. pombe) antibody; Protein GbetaL antibody; Target of rapamycin complex subunit LST8 antibody; TORC subunit LST8 antibody; WAT1 antibody; WAT1 homolog (S. pombe) antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Target of rapamycin complex subunit LST8 protein (159-220AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
Gene References into Functions
  1. NEAT1 was potentially communicated with mTOR signaling target protein mLST8 via the association with miR-181b in type 2 diabetes mellitus. PMID: 28643459
  2. Autophagy regulates c-MET phosphorylation via an mTORC2-dependent mechanism. PMID: 28475179
  3. Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. PMID: 26787466
  4. MLST8 upregulation may contribute to tumor progression. PMID: 25906254
  5. MLST8 polymorphism is associated with gastric cancer. PMID: 23423739
  6. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. PMID: 23594158

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Subcellular Location
Cytoplasm.
Protein Families
WD repeat LST8 family
Tissue Specificity
Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
Database Links

HGNC: 24825

OMIM: 612190

KEGG: hsa:64223

STRING: 9606.ENSP00000380313

UniGene: Hs.29203

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