Target of rapamycin complex subunit LST8 is a protein in humans that is encoded by MLST8 gene. Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.

MLST8 Antibodies

MLST8 Antibodies for Homo sapiens (Human)

MLST8 Antibodies for Human

MLST8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

MLST8 Proteins

MLST8 Proteins for Bos taurus (Bovine)

MLST8 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MLST8 Proteins for Xenopus laevis (African clawed frog)

MLST8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MLST8 Proteins for Homo sapiens (Human)

MLST8 Proteins for Mus musculus (Mouse)

MLST8 cDNA for Danio rerio (Zebrafish) (Brachydanio rerio)

Code Product Name Vector Accession NO.
CSB-CL770424DIL mlst8 pUC NM_199877.2

MLST8 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL863130HU1 MLST8 pUC NM_001199173.1
CSB-CL863130HU2 MLST8 pUC NM_001199174.1
CSB-CL863130HU3 MLST8 pUC NM_001199175.1
CSB-CL863130HU4 MLST8 pUC NM_022372.4

MLST8 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL863590MO1 Mlst8 pUC NM_001252463.1
CSB-CL863590MO2 Mlst8 pUC NM_001252464.1
CSB-CL863590MO3 Mlst8 pUC NM_001252465.1
CSB-CL863590MO4 Mlst8 pUC NM_019988.5


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