Target of rapamycin complex subunit LST8 is a protein in humans that is encoded by MLST8 gene. Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
The following MLST8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MLST8 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA863130LA01HU | MLST8 Antibody |
Human | ELISA, IHC, IF |
CSB-PA863130LB01HU | MLST8 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA863130LC01HU | MLST8 Antibody, FITC conjugated |
Human | |
CSB-PA863130LD01HU | MLST8 Antibody, Biotin conjugated |
Human | ELISA |
MLST8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA770424XA01DIL | mlst8 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
MLST8 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP613776BO CSB-EP613776BO CSB-BP613776BO CSB-MP613776BO CSB-EP613776BO-B |
Recombinant Bovine Target of rapamycin complex subunit LST8 (MLST8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP686297XBF CSB-EP686297XBF CSB-BP686297XBF CSB-MP686297XBF CSB-EP686297XBF-B |
Recombinant Xenopus tropicalis Target of rapamycin complex subunit lst8 (mlst8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP764762XBE CSB-EP764762XBE CSB-BP764762XBE CSB-MP764762XBE CSB-EP764762XBE-B |
Recombinant Xenopus laevis Target of rapamycin complex subunit lst8 (mlst8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP770424DIL CSB-EP770424DIL CSB-BP770424DIL CSB-MP770424DIL CSB-EP770424DIL-B |
Recombinant Danio rerio Target of rapamycin complex subunit lst8 (mlst8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP863130HU CSB-EP863130HU CSB-BP863130HU CSB-MP863130HU CSB-EP863130HU-B |
Recombinant Human Target of rapamycin complex subunit LST8 (MLST8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP863590MO CSB-EP863590MO CSB-BP863590MO CSB-MP863590MO CSB-EP863590MO-B |
Recombinant Mouse Target of rapamycin complex subunit LST8 (Mlst8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |