MMP25 Antibody

Datasheet

Code	CSB-PA198245
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA198245(MMP25 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NPA2

Target Names

MMP25

Alternative Names

Leukolysin antibody; matrix metallopeptidase 25 antibody; matrix metallopeptidase like 1 antibody; matrix metalloproteinase 20 antibody; Matrix Metalloproteinase 25 antibody; Matrix metalloproteinase 25 precursor antibody; Matrix metalloproteinase-25 antibody; Membrane type 6 Matrix Metalloproteinase antibody; Membrane type Matrix Metalloproteinase 6 antibody; Membrane-type matrix metalloproteinase 6 antibody; Membrane-type-6 matrix metalloproteinase antibody; MMP 25 antibody; MMP-25 antibody; MMP20 antibody; MMP20A antibody; MMP25 antibody; MMP25_HUMAN antibody; MMPL1 antibody; MT MMP 6 antibody; MT-MMP 6 antibody; MT6 MMP antibody; MT6-MMP antibody; MT6MMP antibody; MTMMP6 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human MMP25

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May activate progelatinase A.

Gene References into Functions

In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
IL-2-upregulated MT6 cell-surface expression correlates with CD16 downmodulation. MT6, sequestered in intracellular compartments in unstimulated NK cells, translocates to the effector-target cell interface of CD16-mediated immunological synapses. PMID: 23851692
MT6-MMP regulates neutrophil and monocyte chemotaxis and by generating "eat-me" signals upon vimentin cleavage potentially increases phagocytic removal of neutrophils to resolve inflammation. PMID: 22367194
MT6-MMP is present in the membrane, granules and nuclear/endoplasmic reticulum/Golgi fractions of PMNs where it is displayed as a disulfide-linked homodimer of 120 kDa PMID: 20501611
individuals with history of chronic airways inflammation (asthma and COPD) serum leukolysin may be a metabolic marker associated with chronic atopy-associated respiratory inflammation. PMID: 20337648
Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase. PMID: 20308072
MMP25 is regulated by clusterin in vivo PMID: 12860995
MT6-MMP may play a role in colon cancer and exhibit unique biochemical and structural properties that may regulate proteolytic function at the cell surface. PMID: 17513868
the stem region of MT6-MMP is the dimerization interface, an event whose outcome imparts protease stability to the protein PMID: 18936094
MMP-25 plays an important role in multiple sclerosis pathology PMID: 19726693

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Protein Families

Peptidase M10A family

Tissue Specificity

Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.

Database Links

HGNC: 14246

OMIM: 608482

KEGG: hsa:64386

STRING: 9606.ENSP00000337816

UniGene: Hs.654979

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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