MOV10L1 Antibody, Biotin conjugated

Code CSB-PA871604LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MOV10L1 Polyclonal antibody
Uniprot No.
Target Names
MOV10L1
Alternative Names
Cardiac helicase activated by MEF2 protein antibody; Cardiac specific RNA helicase antibody; CHAMP antibody; Csm antibody; M10L1_HUMAN antibody; Moloney leukemia virus 10 like protein 1 antibody; Moloney leukemia virus 10-like protein 1 antibody; MOV10 like 1 antibody; MOV10 like protein 1 antibody; MOV10-like protein 1 antibody; MOV10L1 antibody; Mov10l1; Moloney leukemia virus 10 like 1; homolog (mouse) antibody; Putative helicase Mov10l1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human RNA helicase Mov10l1 protein (336-425AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Gene References into Functions
  1. Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility. PMID: 24817005
Subcellular Location
Cytoplasm.
Protein Families
DNA2/NAM7 helicase family, SDE3 subfamily
Tissue Specificity
[Isoform 1]: Specifically expressed in testis.
Database Links

HGNC: 7201

OMIM: 605794

KEGG: hsa:54456

STRING: 9606.ENSP00000262794

UniGene: Hs.62880

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