MRM2 Antibody, Biotin conjugated

1. Targeted exome sequencing of genes encoding the mitochondrial proteome identified a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein. Our findings establish that defective MRM2 causes a MELAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.3243 A > G negative MELAS-like presentation. PMID: 28973171
2. miR-542-3p functions as a suppressor gene by targeting and upregulating FTSJ2, thus inhibiting the malignancy of non-small cell lung cancer cells PMID: 28866101
3. MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. PMID: 25009282
4. Data show that 2'-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. PMID: 25074936
5. FTSJ2 possesses suppressive effects on the invasion and migration of cancer cells. PMID: 24595062
6. FTSJ2 is a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification. PMID: 11827451

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HGNC: 16352

OMIM: 606906

KEGG: hsa:29960

STRING: 9606.ENSP00000242257

UniGene: Hs.279877