MS4A6A Antibody, Biotin conjugated

1. Meta analysis validated the Alzheimer disease protective association for MS4A6A (rs610932) variants. PMID: 29504051
2. rs610932 MS4A6A is not associated with late-onset Alzheimer's disease. PMID: 28477215
3. these findings reveal that MS4A6A genotypes affect Alzheimer's disease specific brain structures PMID: 27244883
4. Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE and MS4A6A. Results suggest that in addition to APOE, MS4A6A polymorphisms should be considered in hormone trials targeting gonadotropins. PMID: 27337227
5. identified the significant associations of the GBA L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A rs610932 with the delayed AAO of PD. PMID: 27085534
6. Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy. PMID: 26923404
7. high levels of MS4A6A contribute to altered turnover or production of cells with an anti-inflammatory neuroprotective phenotype in favor of cells with a damaging pro-inflammatory phenotype believed to contribute to AD pathology. PMID: 24064185
8. data revealed the allele (T) of the rs3865444 polymorphism of the CD33 gene and the allele (C) of the rs610932 polymorphism of the MS4A6A gene may contribute to Alzheimer's disease risk in the Chinese Han population PMID: 22382309
9. ABCA7 and the MS4A6A/MS4A4E gene cluster are new Alzheimer's disease susceptibility loci. PMID: 21460840

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HGNC: 13375

OMIM: 606548

KEGG: hsa:64231

STRING: 9606.ENSP00000315878

UniGene: Hs.523702