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MT1M Antibody, Biotin conjugated

Datasheet
Code CSB-PA17429D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MT1M Polyclonal antibody
Uniprot No.
Q8N339
Target Names
MT1M
Alternative Names
MT1M antibody; MT1K antibody; Metallothionein-1M antibody; MT-1M antibody; Metallothionein-IM antibody; MT-IM antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Metallothionein-1M protein (1-61AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene References into Functions
  1. Results found that MT1M is downregulated in hepatocellular carcinoma (HCC) tumors, and it suppressed HCC tumorigenesis possibly by inducing cell cycle arrest, enhancing apoptosis and inhibiting cell migration and invasion. These findings provide evidence that MT1M might be a tumor suppressor in HCC tumorigenesis. PMID: 28380433
  2. Low MT1M expression is associated with poor hepatocellular carcinoma prognosis following curative resection. PMID: 27808371
  3. miR-24-3p plays an important role in the initiation and progression of hepatocellular carcinoma by targeting metallothionein 1M. PMID: 27650047
  4. Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas. PMID: 22971577
Protein Families
Metallothionein superfamily, Type 1 family
Database Links

HGNC: 14296

OMIM: 156357

KEGG: hsa:4499

STRING: 9606.ENSP00000369146

UniGene: Hs.647370

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