MTBP Antibody

1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

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HGNC: 7417

OMIM: 605927

KEGG: hsa:27085

STRING: 9606.ENSP00000303398

UniGene: Hs.657656