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MTMR12 Antibody, Biotin conjugated

Datasheet
Code CSB-PA880158LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MTMR12 Polyclonal antibody
Uniprot No.
Q9C0I1
Target Names
MTMR12
Alternative Names
MTMR12 antibody; KIAA1682 antibody; PIP3AP antibody; Myotubularin-related protein 12 antibody; Inactive phosphatidylinositol 3-phosphatase 12 antibody; Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit antibody; 3-PAP antibody; 3-phosphatase adapter protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Myotubularin-related protein 12 protein (188-318AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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MTMR12 Antibodies

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Target Background

Function
Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
Gene References into Functions
  1. Analysis of human XLMTM patient myotubes showed that mutations that disrupt the interaction between myotubularin and MTMR12 proteins result in reduction of both myotubularin and MTMR12 PMID: 23818870
  2. This study does not support the association of PDZD2, GOLPH3, and MTMR12 genes with schizophrenia. PMID: 21451436
  3. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. PMID: 12847286
Subcellular Location
Cytoplasm. Sarcoplasmic reticulum. Cytoplasm, myofibril, sarcomere.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Tissue Specificity
Expressed in skeletal muscles (at protein level). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.
Database Links

HGNC: 18191

OMIM: 606501

KEGG: hsa:54545

STRING: 9606.ENSP00000371577

UniGene: Hs.481836

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