MTMR9 Antibody

Datasheet

Code	CSB-PA847211LA01HU
Size	US$166
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Image	Immunofluorescence staining of A549 cells with CSB-PA847211LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MTMR9 Polyclonal antibody

Uniprot No.

Q96QG7

Target Names

MTMR9

Alternative Names

MTMR9 antibody; C8orf9 antibody; MTMR8 antibody; Myotubularin-related protein 9 antibody; Inactive phosphatidylinositol 3-phosphatase 9 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Myotubularin-related protein 9 protein (322-549AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MTMR9 Antibody (Product code: CSB-PA847211LA01HU) is Non-conjugated. For MTMR9 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA847211LB01HU	MTMR9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA847211LC01HU	MTMR9 Antibody, FITC conjugated
Biotin	CSB-PA847211LD01HU	MTMR9 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine.

Gene References into Functions

Polymorphism of rs2293855 in MTMR9 is associated with measures of glucose tolerance, indices of insulin secretion and indices of insulin sensitivity. PMID: 24937802
MTMR6, which dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis. PMID: 24591580
Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome. PMID: 21796137
Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. PMID: 17855449
MTMR9 greatly enhances the functions of MTMR6 PMID: 19038970

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Subcellular Location

Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily

Tissue Specificity

Expressed in many tissues.

Database Links

HGNC: 14596

OMIM: 606260

KEGG: hsa:66036

STRING: 9606.ENSP00000221086

UniGene: Hs.591395

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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