MX2 Antibody

1. Study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. PMID: 29773792
2. These data demonstrate that human MXB but not other human or murine MX proteins inhibit murine cytomegalovirus propagation. Evidently, the viral protein expression was delayed and the viral DNA amount in nucleus was diminished in MXB expressing cells indicating an obstruction of nuclear entry. PMID: 30032029
3. Therefore, these results demonstrate the importance of MxB in alpha interferon-mediated inhibition of HIV-1 infection. PMID: 29925663
4. The dynamin-like MxB GTPase serves as a broadly acting intracellular restriction factor that controls retrovirus as well as herpesvirus infections. PMID: 29950411
5. MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. [review] PMID: 27492442
6. These experiments suggested that MxB does not contribute to the HIV-1 restriction observed in IFN-alpha-treated human cells. PMID: 26719253
7. Together, the data demonstrate that interferon-beta inhibits foamy virus early in infection and that MxB is not a restriction factor of foamy virus. PMID: 26609934
8. We propose that lower-order oligomerization of MX2 is sufficient for the effective inhibition of human immunodeficiency virus type 1. PMID: 26446602
9. Study analyzed the evolutionary history of MX2 at the inter- and intraspecific level and use this information to identify a haplotype that associates with natural resistance to HIV-1 infection in humans; the ancestral (G) allele of rs2074560 protects from HIV-1 infection with a recessive effect. PMID: 24930137
10. The high prevalence of MxB-resistant mutations in the CypA-binding loop indicates the significant selective pressure of MxB on HIV-1 replication in vivo. PMID: 25571928
11. MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes. PMID: 25348155
12. HIV-seronegative women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV resistance. PMID: 25562491
13. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized. PMID: 25363729
14. MxB oligomerization is important for the ability of MxB to bind to the HIV-1 core proteins. PMID: 25568212
15. A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2. PMID: 25673704
16. structural analysis of assembly of human anti-HIV dynamin-like protein MxB/Mx2 PMID: 25446123
17. MxB binding to the HIV-1 capsid. PMID: 25123063
18. To identify protein domains of MX2 that specify HIV-1 inhibition. PMID: 24899177
19. Through a combination of in vitro evolution and unbiased mutagenesis, authors further map the determinants of sensitivity to Mx2 and reveal that multiple capsid (CA) surfaces define sensitivity to Mx2. PMID: 24760893
20. Taken together, it is concluded that human MxB protein inhibits HIV-1 DNA integration by a CypA-dependent mechanism. PMID: 24055605
21. MX2 is therefore a cell-autonomous, anti-HIV-1 resistance factor whose purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS PMID: 24048477
22. findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest that MX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes PMID: 24121441
23. The MX2 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
24. the MX2 gene to be significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients PMID: 17702266
25. The expression level of the MX2 gene tended to be downregulated in subjects carrying HLA-DQB1*0602, compared with that of the control subjects without this allele. PMID: 18517045

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HGNC: 7533

OMIM: 147890

KEGG: hsa:4600

STRING: 9606.ENSP00000333657

UniGene: Hs.926