MYO5C Antibody

1. MyoVc is unique in taking variable size steps, which are frequently in the backward direction. Results obtained with chimeric constructs implicate the lever arm/rod of MyoVc as being responsible for these properties. Actin bundles allow single MyoVc motors to move processively. PMID: 27498562
2. The myosin V structure reveals the detailed rearrangements underlying myosin force generation as well as the basis of strain-dependent ADP release that is essential for processive myosins, such as myosin V. PMID: 26976594
3. Myo5c-globular tail domain and Myo5a-globular tail domain are not interchangeable in terms of inhibiting the motor function. PMID: 26912658
4. Rab38 and its close homolog Rab32 bind to Myosin Vc but not to Myosin Va or Myosin Vb. Binding depends on residues in the switch II region of Rab32 and Rab38 and regions of the Myosin Vc coiled-coil tail domain. PMID: 25324551
5. Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. PMID: 24339992
6. the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process PMID: 24097982
7. These results provide the first live-cell imaging of Myo5c and indicate that Myo5c functions in secretory granule trafficking. PMID: 19741097
8. myosin Vc is a low duty ratio nonprocessive motor PMID: 18079121
9. Kinetic simulations reveal that the high ADP affinity of actomyosin Vc may lead to elevations of the duty ratio of myosin Vc to as high as 64% under possible physiological ADP concentrations PMID: 18201966
10. related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc PMID: 19008234
11. These data suggest that Myo5c associated with Rab8 is involved in the release of dengue virus 2 from HepG2 cells. PMID: 19641326

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HGNC: 7604

OMIM: 610022

KEGG: hsa:55930

STRING: 9606.ENSP00000261839

UniGene: Hs.487036