NANOS1 Antibody

Datasheet

Code	CSB-PA837878LA01HU
Size	US$166
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Image	Immunofluorescent analysis of Hela cells using CSB-PA837878LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NANOS1 Polyclonal antibody

Uniprot No.

Q8WY41

Target Names

NANOS1

Alternative Names

EC Rep1a antibody; EC_Rep1a antibody; NANO1_HUMAN antibody; NANOS 1 antibody; Nanos homolog 1 (Drosophila) antibody; Nanos homolog 1 antibody; Nanos Homologue 1 (NANOS1) antibody; NANOS1 antibody; Nos 1 antibody; NOS-1 antibody; Nos1 antibody; OTTHUMP00000046853 antibody; Rep 1a antibody; Rep1a antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nanos homolog 1 protein (1-292AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NANOS1 Antibody (Product code: CSB-PA837878LA01HU) is Non-conjugated. For NANOS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA837878LB01HU	NANOS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA837878LC01HU	NANOS1 Antibody, FITC conjugated
Biotin	CSB-PA837878LD01HU	NANOS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

Gene References into Functions

High NANOS expression is associated with retinoblastoma. PMID: 25100735
A group of 195 patients manifesting non-obstructive azoospermia or oligozoospermia were tested for mutations of the NANOS1 gene. PMID: 23315541
Single nucleotide polymorphisms in CYP26B1, NANOS1 and STRA8 genes support involvement of meiotic program initiation in modifying azoospermia and oligozoospermia risk in a Han-Chinese population PMID: 23320086
NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells. PMID: 21800163
Findings describe a new function for hNanos1 as a downstream effector of E-cadherin loss contributing to tumor progression. PMID: 17047063
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. PMID: 18223680
Data demonstrated that SNAPIN interacts additionally with NANOS1 protein. This is the first report demonstrating that the N-terminal region of NANOS1 is necessary for protein binding. PMID: 19168546

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Involvement in disease

Spermatogenic failure 12 (SPGF12)

Subcellular Location

Cytoplasm, perinuclear region. Cytoplasm.

Protein Families

Nanos family

Tissue Specificity

Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermat

Database Links

HGNC: 23044

OMIM: 608226

KEGG: hsa:340719

STRING: 9606.ENSP00000393275

UniGene: Hs.591918

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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